AstraZeneca’s ovarian cancer drug slows disease

Health Watch

LONDON: AstraZeneca’s ovarian cancer drug Lynparza slashed the risk of disease progression in a closely watched clinical trial, boosting its profile against rivals within the novel PARP inhibitor drug class.
The British drugmaker hopes the data from the trial will widen the use of lynparza and help it keep up with competitors racing to broaden the use of PARP medicines. Lynparza and other PARP inhibitors block enzymes involved in repairing damaged DNA, thereby helping to kill cancer cells. They are also being studied against other cancers, including breast and pancreatic tumors.
Women with recurrent ovarian cancer and defective BRCA genes lived a median 19.1 months without their disease worsening when given Lynparza, against 5.5 months for those on placebo, based on disease progression assessments carried out by investigators.
When disease progression was measured by central, blinded review, however, the figure rose to 30.2 months, according to data presented at the Society of Gynecologic Oncology annual meeting on Tuesday. AstraZeneca chief medical officer Sean Bohen said he was “extremely pleased with the results”.
AstraZeneca’s drug became the first of the new class to reach the market when it won US approval at the end of 2014, but it is now only recommended for fourth-line use.
The latest clinical trial is designed to move it up to second-line maintenance therapy, where it would be used for longer periods, significantly increasing its market.
AstraZeneca has developed a new tablet dose reducing the pill intake for patients from 16 capsules to four tablets a day.
Lynparza, which had been abandoned at one stage by AstraZeneca but was revived.
– Reuters

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